Physicians Desk Reference -- 1964 on Oral EDTA
PHYSICIANS DESK REFERENCE 1964 Pp1203-4 CALCIUM DISODIUM VERSENATE® (calcium disodium edetate) Tablets WARNING: Calcium Disodium Edetate is capable of producing toxic and potentially fatal effects. The dosage schedule should be followed and at no time should the recommended daily dose be exceeded. Calcium Disodium Versenate (Calcium Disodium Edetate) Tablets contain 500mg. Of calcium disodium edetate per tablet.
Contraindications:
Calcium Disodium Versenate Tablets should not be given to patients with
severe renal disease. Warnings: See box
above. Chronic oral use of Versenate should not be used as a substitute for adequate measures to avoid undue exposure to lead. Because Versenate chelates other metals, e.g. zinc, copper, etc., the possibility of depletion of such metals in persons taking Versenate on a long-term basis should be considered, and steps taken to avoid such deficiencies. Although urinary excretion of lead usually does increase following administration of Versenate, there is the possibility that, in come cases, a concomitant decrease in fecal excretion occurs. If this were to happen, the total amount of lead excreted might appear greater than is actually the case. Usage in
Pregnancy: The safe use of calcium disodium edetate has not been
established with respect to possible adverse effects upon fetal
development. Therefore, it should not be used in women of child-bearing
potential and particularly during early pregnancy unless, in the judgment
of the physician, the potential benefits outweigh the possible hazards. Precautions:
The drug should be used with caution in tuberculosis, active or
healed, and in the presence of renal disease. Adverse Reactions:
Calcium Disodium Versenate when administered orally may act as a
gastrointestinal irritant in some patients, producing diarrhea, abdominal
cramps, and vomiting. Such symptoms are more likely to occur when the
daily dose exceeds 3gms. Other side actions reported in a relatively small
percentage of patients were leg and other muscle cramps, weakness,
malaise, and albumin or red cells in the urine. None of the side actions
is considered to be serious when detected early. Excessive doses may
result in renal toxicity. Dosage and
Administration: Adults: The average daily dosage is 8 tablets
(4gm.) in divided doses. Children: Two tablets (1gm.) daily per
35 pounds of body weight in divided doses.
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