Vitamin C and Scurvy
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Vitamin C and Scurvy
Vitamin
C (ascorbic acid), a reducing agent, is necessary to
maintain the enzyme prolyl hydroxylase in an active
form, most likely by keeping its iron atom in a reduced
state. The precursor molecule to the protein collagen,
procollagen, contains an unusual amino acid sequence in
that every third amino acid is a glycine and contains a
high frequency of two amino acids not found in any
other proteins - hydroxyproline and hydroxylysine.
These latter two amino acids are converted from proline
and lysine, respectively, after the procollagen
molecule has been synthesized. The hydroxylation of
proline and lysine in procollagen is carried out by the
enzyme prolyl hydroxylase using vitamin C as a
cofactor.
A vitamin C deficiency results in an underhydroxylation of proline and lysine in collagen which results in a lower melting temperature of the resulting collagen fibers which causes a breakdown of the protein collagen needed for connective tissue, bones and dentin, the major portion of teeth. Collagen is a cementing material that binds cells together, and is an essential connective tissue protein in the body. Whenever the body is wounded, collagen glues the separated tissues together to form a scar.
A lack of collagen causes the walls of the body's blood capillaries to break down and hemorrhaging occurs in cells throughout the body. When capillaries lose the "glue" that holds them together, symptoms of scurvy appear.
An affected person becomes weak and has joint pain. Internal hemorrhages cause black-and-blue marks to appear on the skin. At the first visible signs of scurvy, raised red spots appear on the skin around the hair follicles of the legs, buttocks, arms and back. When the tiny capillaries of the hair follicles hemorrhage, the hair-producing cells do not receive the nourishment needed for the hairs to grow normally. Consequently, the skin becomes flecked with small lesions that begin to appear on the body after about five months on a diet deficient in vitamin C. These lesions were the "spots" that James Lind observed on the skin of his sick men. Gums hemorrhage and their tissue becomes weak and spongy. Dentin, which lies below the enamel and is part of the root of teeth, breaks down. Teeth loosen and eating becomes difficult and painful. A personal account of scurvy.
James Lind's observation that citrus fruits contained something that counteracted the ravages of scurvy was followed by his development of a method for the concentration and preservation of citrus fruit juices for use at sea. In 1795, the British Royal Navy provided a daily ration of lime or lemon juice to all its men. English sailors to this day are called "limeys", for lime was the term used at the time for both lemons and limes. It was not until 1932, that W.A. Waugh and C.G. King at the University of Pittsburgh, and Albert Szent-Gyorgyi, a Hungarian scientist, isolated and synthesized ascorbic acid, or vitamin C.
Curiously, only primates and guinea pigs are unable to manufacture vitamin C on their own, having lost the genetic information necessary for the production of this important cofactor.
Anyone with Cancer or concerned about it should be aware of the Beard/Kelley/Gonzalez theory and therapy
In theory, failure of the pancreas leads to malignancy. According to this 100 year-old theory, and treatment (that Sloan-Kettering admits has a 100% effectiveness rate in their examination of the only trial), cancer is the growth of a placenta-like trophoblast cell. In other words, cancer is like a pregnancy gone awry. Normally our pancreas creates enzymes that control these cells.
To the extent that vitamin C and other nutrients detoxify, heal and repair the pancreas, under this theory, cancer would be controlled due to the improved health of the pancreas.
Dr. Matthias Rath has also found that vitamin C/lysine/proline and green-tea extract deactivate an enzyme that tumors use to spread.
So even under this theory, vitamin C can help to control the spread of cancer in multiple ways.
We like this theory. Dr. Nicholas Gonzalez has a 6-million dollar NIH grant to study the Kelley approach. We may all soon know if a failed pancreas is indeed the answer to cancer. - Owen Fonorow
The definitive scientific evidence demonstrating the efficacy and safety of Vitamin C for cancer treatment |
Contrary to popular misconception, fed by the Media; antioxidants, vitamin C in particular, are powerful weapons in the fight against cancer. But there is a question. How or why would Medical Science not know or be on the wrong track?
A former New York state assemblyman found the answer. If you or someone you know has cancer, read POLITICS IN HEALING: The Suppression and Manipulation of American Medicine by Dan Haley. This important, easy to read, gripping book contains more than FIVE outright cancer cures. And Haley restricted himself to public records and found sworn court testimony, including heads of the AMA.
After reading Haley's book, you'll want to know more about:
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Cessium Chloride and The High pH Therapy for Cancer Best results when combined with high doses of vitamin C, vitamin A, zinc, selenium and Laetrile.
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Today's version of William Koch's glyoxylide?
Even the mainstream is slowing recognizing value of vitamin C in the fight against cancer.
Animal-Based Nutrients Linked With Higher Risk Of Stomach And Esophageal Cancers Vitamin C supplements reduce stomach cancer by 40% Yale researchers also found that regular users of vitamin C supplements were at significantly lower risk of stomach cancer
Vitamin C and Vitamin K3 cause massive cancer cell death From Science News.
[Irwin Stone, The Healing Factor, Pg 95] |
Hugh Riordin
This really works. We have been playing around with too low doses.
This is the link to Riordan's best paper on the treatment of cancer with IVC.
Ralph Moss: Antioxidants Against Cancer
Must Read for both Cancer patients and Oncologists
Has the recent spate of negative publicity about antioxidants interfering with cancer treatment confused you? We highly recommend the new book by Ralph Moss, a leading expert on cancer treatments.
Antioxidants Against Cancer is an excellent evidence-based summary, easily understood by both patients and their cancer treatment specialists. Ralph Moss's latest book shows why antioxidant therapy should be offered to every cancer patient.
Update on the latest science of Antioxidants and Cancer by Ralph Moss
The following is from the Moss book:
| Agent Used | Decrease in Cancer Growth |
|---|---|
| Vitamin C | -5.0% |
| 5-FU | 38.0% |
| 5-FU + Vitamin C | 95.5% |
| X rays | 72.0% |
| X rays + Vitamin C | 98.2% |
| Bleomycin | 73.0% |
| Bleomycin + Vitamin C | 92.0% |
| Agent Used | Decrease in Cancer Growth |
|---|---|
| Vitamin E | 47% |
| Bleomycin | 46% |
| Bleomycin + Vitamin E | 71% |
| 5-FU | 37% |
| 5-FU + Vitamin E | 71% |
| Adriamycin | 58% |
| Adriamycin + Vitamin E | 88% |
| Cisplatin | 57% |
| Cisplatin + Vitamin E | 82% |
Source: Kedar Prasad, University of Colorado, as summarized in Antioxidants Against Cancer by Ralph Moss
Vitamin C Foundation comments: Are high antioxidant intakes bad for your health?
Hoffer's New Book Vitamin C and Cancer Now Available
The vitamins-as-prevention paradigm shift to vitamins-as-therapy is documented in this heavyweight text from the pioneer of orthomolecular medicine. Hoffer covers the surprising outcomes of cancer patients treated with megadoses of vitamin C. This book should assuage any fears that cancer patients may have about taking vitamin C during their treatment.
In stock. $14 + S&H. Contact the Foundation to order.
The following case study is from the Hoffer book. This patient (Case #351) was diagnosed with lung cancer,
Born in 1932, she was first seen in June 1991. In May 1991 she suffered the flu and cough. On routine x-ray a shadow was observed in her lung which had apparently been there one year before. A biopsy was positive. At first she refused to have surgery but later agreed to it in July. Three years earlier she had a myocardial infarct, later angina, and in January 1989 she had angioplasty. She had started to take vitamin C 6 grams per day, coenzyme Q10 200 mg, and beta carotene. I advised her to increase the vitamin C to 12 grams, to add niacin 1.5 grams, B complex-50, beta carotene 75,000 IU, vitamin E 800 IU, selenium 600 mcg, zinc citrate 50 mg, and folic acid 10 mg, all daily. On 11 June 1992 she was well and felt good. On 22 February 1994 she was getting on well. Again in June 1996 she was well." [Vitamin C and Cancer: Discovery, Recovery, Controversy, A. Hoffer, 2000]
Back to the Vitamin C Foundation
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