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Magnesium -- Possible Remedy For Rapid Heart Beat

Magnesium ...1......2... ...3...

Source

Also read about a source for Magnesium

MAGNESIUM

Because of the competing nature of calcium and magnesium, excessive calcium intake from foods or supplements can lead to a magnesium deficiency. The symptoms of magnesium deficiency are identical with many of the symptoms of thyroid disease, especially hyperthyroidism. People of Asian descent who get hyperthyroidism often become completely rigid and may be found lying in the streets this way. The condition is called hypokalemic periodic paralysis and is highly associated with hyperthyroidism. It's possible that the origin of the disease is not from low potassium (hypokalemia) but from low magnesium, which we know is a factor in hyperthyroidism.

Functions: 

The principal function of magnesium that is critical in thyroid disease is that it enables muscles to relax. With inadequate magnesium, the muscles cramp. When this happens to the heart muscles the heart does not go through a complete relaxation phase, and the next calcium-driven contraction begins before the relaxation is complete. This results in rapid heart beat and irregular heart rate known as arrhythmia.

Deficiency Effects and Symptoms:

According to the Nutrition Almanac, "Magnesium deficiency can easily occur because magnesium is refined out of many foods during processing. Cooking food removes the minerals; the oxalic acid in foods like spinach and phytic acid found in cereals bind magnesium in the body, as do unbalanced amounts of salts....A deficiency can occur in people with diabetes, those who use diuretics or digitalis preparations, the elderly, those with pancreatitis, chronic alcoholism, kwashiorkor, pregnancy, cirrhosis of the liver, arteriosclerosis or kidney malfunction, those on low-calorie or high-carbohydrate diets, and those who have severe malabsorption such as that caused  by chronic diarrhea or vomiting....Fluoride, high zinc levels, high levels of vitamin D, diuretics, and diarrhea will cause a deficiency of magnesium."

Also from N. A.: "Magnesium deficiency is thought to be closely related to coronary heart disease, including myocardial necrosis. An inadequate supply of this mineral may result in the formation of clots in the heart and brain and may contribute to calcium deposits in the kidneys blood vessels, and heart. Heart failure resulting from fibrillation and lesions in the small arteries is linked to a deficiency of magnesium, as is vasodilation, which is followed by hyperkinetic behavior and fatal convulsions."

"Symptoms of a deficiency may include gastrointestinal disorders, irregular heart rhythm, lack of coordination, muscle  twitch, tremors, weakness, apprehensiveness, personality changes, disorientation, confusion, depression, and irritability. A deficiency interferes with nerve and muscle impulses. Long-term deficiency can lead to tetany as in a calcium deficiency, alcoholic hallucinations, unusual face and eye movement, alopecia (baldness), swollen gums, and lesions of the gums."

Beneficial Effects:

N.A.: "Magnesium is vital in helping prevent heart attacks....After a heart attack, it has been found that supplementation provided a much higher survival rate and showed far less life-threatening dysrhythmias....It has also proved beneficial in the treatment of neuromuscular disorders, nervousness, tantrums, depression, sensitivity to noise, and hand tremor....Supplementing helps control dizziness, muscle weakness, twitching, heart disease, and high blood pressure,....reduce blood cholesterol and keep the arteries healthy....used for controlling convulsions in pregnant women, premature labor, and epileptic seizures."

Chocolate is a good source of magnesium and has a high magnesium to calcium ratio (about 4:1). Magnesium is low in hypers and the craving for chocolate may be driving my a need for magnesium. Unfortunately, chocolate may also be high in cadmium which is a probably negative factor for hyperT. Thus the craving for magnesium, if satisfied by eating chocolate, could exacerbate the symptoms of hyperT.

In this first study we see that magnesium is depleted in the  hyperthyroid state and treatment by Methimazole increases the magnesium content of both erythrocytes (red blood cells) and serum.  This emphasizes the need for magnesium supplementation in hyperthyroidism.

Title
Magnesium metabolism in hyperthyroidism.
Author
Disashi T; Iwaoka T; Inoue J; Naomi S; Fujimoto Y; Umeda T; Tomita K
Address
Third Department of Internal Medicine, Kumamoto University School of Medicine, Japan.
Source
Endocr J, 43(4):397-402 1996 Aug
Abstract
Changes in magnesium metabolism, along with those in sodium, were investigated in 17 patients with Graves' disease (14 females and 3 males, mean +/- SD, 44.8 +/- 12.2 years) and their relationship to plasma levels of thyroid hormones were assessed before and after treatment. Each patient was studied in hyperthyroid state and euthyroid state after treatment. Each patient was studied in hyperthyroid state and euthyroid state after treatment with methimazole. Treatment with methimazole increased the magnesium concentration both in erythrocytes (2.00 +/- 0.18 vs. 2.08 +/- 0.24 mmol/l cells, P < 0.05) and in serum (0.72 +/- 0.12 vs. 0.84 +/- 0.11 mmol/l, P < 0.001) but both urinary output and fractional excretion of magnesium decreased significantly (P < 0.05 and P < 0.001, respectively). The erythrocyte sodium concentration decreased with treatment (10.7 +/- 2.6 vs. 8.1 +/- 1.1 mmol/l cells, P < 0.001) but the serum sodium remained unchanged (140.9 +/- 1.9 vs. 140.9 +/- 2.1 mmol/l, NS). Urinary excretion of sodium also decreased with treatment (P < 0.05), but only changes in indices of magnesium metabolism (decrease in renal fractional excretion, rise in serum level) correlated significantly with those of the thyroid functions with treatment. These observations clearly indicate that in Graves' disease, the magnitude of magnesium metabolism alteration is closely related to the extent of the increase in thyroid hormones in plasma.

This second study examines the effect of magnesium on the sodium-potassium pump in the heart.  Magnesium deficiency is demonstrated to leave the number of pumps unaltered but to decrease the activity of the pumps.  This appears to result in an increase of sodium inside the cells with consequent arrhythmias in the heart.  This is evidence that supplementing magnesium can control rapid and irregular heartbeat experienced in hyperthyroidism.

Title
Effects of dietary magnesium on sodium-potassium pump action in the heart of rats.
Author
Fischer PW; Giroux A
Address
Nutrition Research Division, Health and Welfare Canada, Ottawa, Ontario.
Source
J Nutr, 117(12):2091-5 1987 Dec
Abstract
Sprague-Dawley rats were fed a basal AIN-76 diet containing 80, 200, 350, 500 or 650 mg of magnesium per kilogram of diet for 6 wk. Ventricular slices, as well as microsomal fractions, were prepared from the hearts and were used to determine sodium-potassium pump activity. Sodium-potassium pump activity was assessed in the microsomal membranes by determining the ouabain-inhibitable Na+, K+-ATPase activity and [3H]ouabain binding, and in the ventricular slices, by determining ouabain-sensitive 86Rb uptake under K+-free conditions. The ATPase activity increased with increasing dietary magnesium, so that in the hearts of those animals that were fed 500 and 650 mg of magnesium/kg diet, it was significantly greater than the activity in the hearts of the animals fed 80 and 200 mg/kg diet. Similarly, 86Rb uptake by heart slices from rats fed 500 and 650 mg of magnesium/kg diet was significantly greater than the uptake by heart slices from animals fed 80 and 200 mg/kg diet. [3H]Ouabain binding did not change with increasing dietary magnesium. Thus, magnesium deficiency appears to have no effect on the number of sodium-potassium pump sites, but does decrease the activity of the pump. It is suggested that this leads to an increase in intracellular Na+, resulting in a change in the membrane potential, and may contribute to the arrhythmias associated with magnesium deficiency.

The following study suggests that boron is essential for proper magnesium metabolism. Also, this study may shed light on why fructose increases the severity of a copper deficiency--it causes adverse effects when magnesium is low.

Magnes Res 2000 Mar;13(1):19-27  

Magnesium deficiency in the rat: effects of fructose, boron and copper.


Kenney MA, McCoy JH

School of Human Environmental Sciences, University of Arkansas, Fayetteville 72701, USA. kenney@comp.uark.edu

Magnesium (Mg) participates in many biochemical reactions which involve a variety of other nutrients. To elucidate some nutrient interactions, fructose (FR) and starch (ST) were compared as carbohydrate sources, and boron (B) and copper (Cu) were added to low-Mg diets for young male rats. Lack of Mg always caused characteristic deficiency symptoms. FR resembled Mg deficiency in effects on body, liver, and kidney weights and on plasma cholesterol level, but did not affect serum Mg or calcium (Ca). FR effects apparently were not mediated by changes in plasma Mg and Ca concentrations and were not prevented by adding Cu. B appeared to lessen effects of a low-Mg diet on body growth, serum cholesterol, and ash concentration in bone, but exacerbated deficiency symptoms, without affecting the concentration of Mg or Ca in serum. Results suggest that increased FR intake and marginal B might adversely affect individuals whose Mg status is suboptimal.

 

In the following study we see that nearly half of patients complaining of chronic fatigue symptoms and fibromyalgia (companion diseases to hypothyroidism) have magnesium deficiencies.

Magnes Res 1997 Dec;10(4):329-37  

Magnesium deficit in a sample of the Belgian population presenting with chronic fatigue.


Moorkens G, Manuel y Keenoy B, Vertommen J, Meludu S, Noe M, De Leeuw I

Department of Internal Medicine, University Hospital, Antwerp, Belgium.

97 patients (25 per cent males, ages ranging from 14 to 73 years, median 38 years) with complaints of chronic fatigue (chronic fatigue syndrome, fibromyalgia or/and spasmophilia) have been enrolled in a prospective study to evaluate the Mg status and the dietary intake of Mg. An IV loading test (performed following the Ryzen protocol) showed a Mg deficit in 44 patients. After Mg supplementation in 24 patients, the loading test showed a significant decrease (p = 0.0018) in Mg retention. Mean values of serum Mg, red blood cell Mg and magnesuria showed no significant difference between patients with or without Mg deficiency. No association was found between Mg deficiency, CFS or FM. However serum Mg level was significantly lower in the patients with spasmophilia than in the other patients.

PMID: 9513929, UI: 98175116
 
The following study also shows that fibromyalgia is associated with magnesium deficiency.  Very importantly it also indicates that magnesium deficiency may be a consequence of thiamine (vitamin B-1) deficiency and that selenium status is slightly correlated with magnesium levels.  This shows that there is some interdependence of selenium and magnesium and that thiamine may be critical for magnesium metabolism and possibly selenium metabolism.
 
Magnes Res 1994 Dec;7(3-4):285-8  

Selenium and magnesium status in fibromyalgia.

Eisinger J, Plantamura A, Marie PA, Ayavou T

Centre Hospitalier de Toulon, France.

Muscle pain has been associated with magnesium (Mg) and selenium (Se) deficiency: magnesium and selenium status were investigated in fibromyalgia (FM). Erythrocyte (E), leucocyte (L) and serum (S) magnesium, serum selenium and zinc, and vitamin B1, B2, A or E status were assessed in 22 patients with fibromyalgia and in 23 age-matched healthy controls. LMg is significantly increased (P < 0.05) and EMg slightly decreased in fibromyalgia. These magnesium abnormalities are associated with previously-reported impairment of thiamin metabolism. Antioxidant status (as well as plasma malondialdehyde) is unchanged in fibromyalgia and serum selenium levels, slightly but not significantly correlated with serum magnesium, is normal.

PMID: 7786692, UI: 95306266
 
The following study indicates that riboflavin (vitamin B-2) is not involved in magnesium metabolism. 
 
Magnes Res 1993 Jun;6(2):165-6  

Absence of correlation between magnesium and riboflavin status.

Eisinger J, Clairet D, Brue F, Ayavou T

Department of Rheumatic Diseases, Centre Hospitalier, Toulon, France.

Erythrocyte magnesium and glutathione reductase activity coefficient (EGR-AC), reflecting vitamin B-2 status, were assessed in 11 athletes, 20 patients with fibromyalgia, 18 patients with hypothyroidism, and 13 controls. No correlation was demonstrated between erythrocyte magnesium and EGR-AC.

PMID: 8274362, UI: 94100069

Subj: [hyperthyroidism] Re: InsomniaAnxiety

Date: 3/22/00 7:29:13 PM Pacific Standard Time

From: ramathomas@cco.net (Mary Ann Thomas)

Reply-to: hyperthyroidism@egroups.com

To: hyperthyroidism@eGroups.com

Cire, You mention that you take 300mg of magnesium with 600mg of calcium and there is a bit of talk surrounding whether or not these two should be supplemented in a 2 to 1 ratio or 1 to 1 ratio. I think John recommends something closer to a 1 to 1 ratio and I would like to share my personal experience with calcium and magnesium supplementation.

I recently saw a Naturopath Physician who had me taking calcium and magnesium in a ratio higher than two to one (I can't remember the exact ratio right now). At this higher than recommended ratio I began having trouble sleeping. Most nights I couldn't get to sleep and when I did I would wake up a couple of hours later and be awake for several hours.

My back and neck also started giving me more problems than normal. I had eye twitches and readily pulled muscles just from sleeping! My thyroid grew to four times it's "normal" size.

When I finally reviewed my supplement list and discovered the imbalance in the calcium and magnesium ratios I adjusted my ratio back to one to one and all the above problems were alleviated including getting a full nights sleep. I currently take 1200mg of magnesium to 600mg of calcium and find that works about best for me. Perhaps you should consider raising your magnesium.

Good Health to All!

MA

Subj: [hyperthyroidism] Re: Insomnia/Anxiety

Date: 3/22/00 8:14:20 PM Pacific Standard Time

From: mrej@centurytel.net (Cire)

Reply-to: hyperthyroidism@egroups.com

To: hyperthyroidism@eGroups.com

Mary, i think you're right. I mixed a teaspoon of Epsom salts in water and drank it this afternoon. I noticed i started to yawn and feel better. I took another dose at dinner time and once again it seemed like it helped. I will be looking into taking more magnesium. I know the plants like it so maybe there's a link here? Wouldn't it be something if it was as simple as magnesium deficiency? Thanks to all for the support and insight, I really appreciate it.

 


 
Source

The Importance

Learn more about the Author, Peter Gillham

Magnesium is the most important major mineral that is needed by your body. In order to function correctly and efficiently your body needs many nutrients. But if it is deficient in magnesium, there are over 300 biochemical reactions that either won't occur at all or will occur very inefficiently. Somewhat like a car functioning with dirty battery terminals.

Also, magnesium is necessary for the correct assimilation of calcium and potassium and the correct and efficient functioning of enzymes. As you can imagine, without magnesium your body is going to be performing at very much less than full capacity. A deficiency in magnesium can go from slight to very severe and your body will be signaling to you that it is in trouble: SOS . . . HELP!

   
Body Symptoms
These signals are in the form of body symptoms. A slight deficiency and you will notice slight depression and lack of well-being. The body is telling you, Help, I'm in trouble. Then you start getting headaches, pain in the lower back, stiff, tight muscles, particularly in the back. The body is telling you, I'm in worse trouble, help me! Now!

But you ignore these messages. You haven't learnt to read and decipher them. You seek professional advice and . . . Well, you know what they advise.

Time goes by and now you start getting muscle cramps, then calcium deposits, muscle twitches and tics, high blood pressure. You ignore it and don't do anything about these signals.

You start to get nervous; you jump at sudden sounds. You have never been this way before. You are told that you are getting old, that you can expect this sort of thing. You now have trouble sleeping and continually wake up feeling tired. Your body goes into spasms (involuntary and abnormal muscular contractions) and jerks. Your body is calling out, You idiot, I need help now! Get some magnesium drink and take it night and morning!

Don't Ignore Warning Signals
You ignore these signals. Next, you find yourself with a chest pain, called angina pectoris. You ignore this also, and no one else seems to know what is causing it. You never did learn how to take care of your own body and have always left it to the so-called experts. These experts don't know either.

The next thing that happens is suddenly your heart starts racing. It goes out of rhythm. You don¹t know what to do and neither does anyone else. Then one day you have been out working hard physically, or under stress, and all of a sudden you have a heart attack. Your body is telling you, I am in real trouble; I am almost at the end of the line. I need magnesium urgently and fast. NOW! So learn from me: The body is crying out for magnesium. It is deficient in magnesium. It cannot function unless it has sufficient of this mineral.

I know this seems too simple.

Test it for Yourself
Prove me wrong. But in the test, use the correct magnesium product—otherwise you won¹t get the required results.

How important is magnesium? It is so important that your body won¹t function well with even a slight deficiency, and with a severe deficiency you could end up with a heart attack. So you tell me. Is magnesium important enough for you to learn about and consume?

Key Nutrient
Magnesium is an essential nutrient. It is necessary for every major biochemical process, such as digestion, protein synthesis, cellular energy production and glucose metabolism. Magnesium is also needed for bone strength, muscle strength and heartbeat, as well as the functioning of the nervous system. Over three hundred biochemical and bioelectric reactions depend on magnesium to occur. Without these taking place efficiently, the body is in trouble and so are you.

If you do not have sufficient magnesium, the body will not work properly and you will end up with the symptoms described earlier. By your drinking a good magnesium drink, these symptoms will gradually and mysteriously disappear. This will occur even if you only take a small amount of it. (For more info on Natural Calm water soluble magnesium, click here.)

Deficiency is Common
Contrary to common belief, magnesium deficiency is very common even among those who supplement it regularly. The reason for this is that the stress of modern lifestyle depletes magnesium reserves far more rapidly than was previously realized.

Activates Other Minerals
All other major minerals are dependent upon magnesium being present in order to function.

The major minerals are magnesium, calcium, potassium and sodium. Of these, magnesium is by far the most important.

Magnesium versus Calcium
Calcium, a major mineral, needs magnesium in order to assimilate into the body. Calcium, however, should never be taken on its own. Otherwise, it will pull magnesium out of body parts in order to assimilate. This creates a greater magnesium deficiency and the person will feel worse. This occurs with people who drink milk. Milk is about 8 calcium to 1 magnesium and it will create a magnesium deficiency.

Magnesium regulates the entrance and utilization of calcium in the cells. Without magnesium, calcium remains in the body unused. This will result in calcium deposits in the joints (often called arthritis), gallstones, kidney stones, and in extreme cases calcification of the brain and other body organs and parts. This, in turn, results in loss of memory and loss of ability to reason and eventually the termination of life. All of these conditions have frequently been known to disappear after taking extra magnesium, especially the drink form (For more information, click here.).

Again, magnesium and calcium must be in the correct proportions, otherwise the calcium becomes a pollutant in the body causing heart disease, arthritis, hardening of the arteries, senility, osteoporosis, and calcification of organs and tissues as described earlier, which could eventually completely degenerate these organs and tissues. From this you can deduce that it is contra survival to take calcium without magnesium. The rule is "Never take calcium without magnesium. Calcium depends on magnesium for it to assimilate. Magnesium, on the other hand, doesn't require calcium in order to function. In fact, in many cases, magnesium taken on its own without any calcium will help you feel younger, more energetic, stronger, and give you a multitude of other benefits, all as a result of the magnesium being present to do its job.

What Depletes It?
Let¹s take a look at what depletes magnesium: Modern stresses, whether chemical, environmental or mental, frequently deplete magnesium reserves (which are often depleted faster than calcium reserves). This can cause a magnesium deficiency and the resultant symptoms of internal stress, even when the person does take magnesium supplements if he takes more calcium than magnesium (which is very common). Extra magnesium can often mean the difference between a stressed body and a completely relaxed one. Magnesium depletion is a highly important issue, which will be crucial to understand. The following are Magnesium Depletors. Learn them well and apply accordingly. The more dominant they are in your life, the more magnesium your body will need. These items dramatically speed up the depletion of your body's magnesium storage, and make it necessary for much more magnesium to be consumed:

  1. Mental stress,
  2. Physical stress,
  3. Coffee,
  4. Sugar,
  5. High sodium diet,
  6. Alcohol,
  7. Cola-type sodas,
  8. Tobacco,
  9. High perspiration,
  10. Medical drugs of all types,
  11. Low thyroid,
  12. Diabetes,
  13. Chronic pain,
  14. Diuretics,
  15. A high carbohydrate diet
  16. A high calcium diet.

Calcium? Yes. Can too much calcium be a problem? More than you ever thought possible. Differently put, excess calcium can become a real problem. Excess magnesium, on the other hand, is impossible. Excess calcium combined with low magnesium will create osteoporosis and fragile bones.

The Proof?
Here is an amazing example: What country has the highest rate of milk consumption? That¹s right, it is America. Now another question: What country has the highest consumption rate of calcium supplements? That¹s right, the answer is again America. So obviously, you would say, America must have the lowest occurrence of osteoporosis (calcium loss) of all countries, right? Believe it or not, the truth is the exact opposite! We have the highest rate! Why? Taking more calcium will not fix a calcium deficiency, which is quite evident from the statistics. Yet more magnesium will handle the calcium deficiency as well as the magnesium deficiency itself.

 


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