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Questran -- One Of The Original Cholesterol Lowering Drugs  -- From Bristol Myers

Source

Cholesterol Lowering Drugs
clearesterol (evolvE®) Bionutrics, Inc., (CarDiermTM ) Smartbasics
cervastatin (Bayco®) Bayer
atorvastin (Lipitor®) Parke Davis
lovastatin (Mevacor®) Merck
cholestyramine (Questran®) Bristol Myers Squibb
colestipol (Colestid®) Pharmacia Upjohn

Questran was the original cholesterol-lowering drug used during the corrupt tests approved by the National Blood, Heart, and Lung Institute (Dr. Claude Lenfant).  It lost out in the final bribery bidding, to Mevacor, and both of these are now not much used in the US because Lipitor has taken over.

It is good to see that the original drug corrupter, the manufacturer of Questran, is finally getting its just deserts:


The Wall Street Journal  

April 5, 2002

HEALTH

Bristol-Myers Shares Decline 15%;
Takeover Talk Sweeps Wall Street

By GEETA ANAND and MICHAEL WALDHOLZ
Staff Reporters of THE WALL STREET JOURNAL
 

RELATED ARTICLES
 Bristol-Myers Expects Slow Sales6
04/02/02
 
 Bristol-Myers Pins Hopes to Vanlev7
03/20/02
 
 Bristol-Myers, ImClone Reconcile Differences8
03/06/02
 
 


COMPANIES
Dow Jones, Reuters
Bristol-Myers Squibb Co. (BMY)
PRICE
CHANGE
U.S. dollars
32.11
-0.04
11:03 a.m.


 
 

* At Market Close

As Bristol-Myers Squibb Co.'s stock sank almost 15% following the company's latest earnings warning, executives worried about takeover speculation and hunkered down to contemplate further changes in management and strategies to help it remain independent, according to a person familiar with top management.

Chairman Peter Dolan Thursday was directing his focus internally on fixing the company and repairing badly damaged morale, while speculation swept Wall Street that the company could be a takeover target. On Wednesday after the market's close, the New York drug company shocked investors by projecting that its earnings this year may amount to half of last year's and announcing the departure of the president of pharmaceutical operations.

[hc dolan]

The shares slid in response. Bristol's stock ended at $32.15, down $5.55 in 4 p.m. New York Stock Exchange composite trading. The company's stock is off 46% from its 12-month high of $60 and now has a market capitalization of about $78 billion. The selling was accompanied by withering attacks from analysts and money managers who voiced their skepticism that Mr. Dolan can turn the company around, and predicting that the company would become the target of a hostile takeover bid. Speculation centered on two European drug companies, GlaxoSmithKline PLC and Novartis AG.

"It's not possible for it to survive as it is. The stock is too cheap," said Hemant Shah, an independent pharmaceutical analyst in New Jersey. "I am convinced that six months from now, we won't have a Bristol-Myers Squibb."

The company said it won't comment on takeover rumors but it has said it isn't interested in a merger with another pharmaceutical firm. A person familiar with the top management said emphatically that Bristol-Myers "is determined to remain independent," and is putting in place the management and strategies to ensure that.

Standard & Poor's announced it had put Bristol-Myers's corporate credit rating on CreditWatch, which means it is considering downgrading the company's triple-A rating. This would be a big blow for Bristol-Myers, which for years has been one of less than a dozen major corporations in the world with triple-A ratings from both S&P and Moody's Investors Service. Losing its top-notch ratings would both wound its pride and make borrowing more expensive.

Standard & Poor's, however, said the company's A-1-plus short-term corporate credit and commercial paper ratings wouldn't be affected.

The 46-year-old Mr. Dolan, who took over as chairman and chief executive just last May, declined to be interviewed. Previously, he has said he believed the company didn't need to merge, and that a merger would cause more distractions and other problems than it solved.

Analysts weren't thrilled with the news that Mr. Dolan -- who has little pharmaceutical background -- would take control of that operation from Richard Lane, the pharmaceuticals president who will be leaving the company. "So that's supposed to make us feel really comfortable?" asked Barbara Ryan, an analyst at Deutsche Banc Alex. Brown.

Mr. Dolan will have some help: Donald J. Hayden, executive vice president, was named to head the North American medicines business. Mr. Lane couldn't be reached for comment.

Ms. Ryan and others on Wall Street said Mr. Dolan needed a "sacrificial lamb" to blame for the company's troubles and so Mr. Lane's departure made sense. But they said they wouldn't view any other departures favorably, in particular that of research chief Peter Ringrose, who joined from Pfizer Inc. in 1997.


[Bad News]

Click on dates for related articles

1. Dec. 13, 20011 Warns 2002 earnings will fall short of expectations, citing higher R&D costs and sharp dropoff in sales of diabetes drug Glucophage to generics.

2. Dec. 28, 20012 ImClone Systems, in which Bristol-Myers invested heavily, says FDA refused to review its cancer drug, Erbitux.

3. Jan. 24, 20023 Writes off $735 million of $1.2 billion investment in ImClone.

4. March 20, 20024 Experimental heart drug Vanlev fails to show benefits over rival treatments.

5. April 1, 20025 Warns that sales will suffer because wholesalers' inventories are bloated.

6. April 4, 2002 Shares fell almost 15% after the company cut first-quarter and full-year earnings and revenue expectations.


"He needs to retain the people he has left because so many key people have already left," said C.J. Sylvester, an analyst with UBS Warburg.

Wall Street was abuzz Thursday with speculation over which company might make a takeover bid for Bristol-Myers.

"The question is whether there is any other way out," besides a takeover, said Viren Mehta, an analyst for Mehta Partners in New York. He said he believed Bristol-Myers's shortage of new products "creates an untenable situation" for the drug maker.

Takeover speculation focused on GlaxoSmithKline, Novartis, Sanofi-Synthelabo SA and Pharmacia Corp. Spokesmen for all four companies declined to comment on whether they were eyeing Bristol-Myers.

London-based GlaxoSmithKline urgently needs to fill its late-stage pipeline and has always wanted to boost its position in the crucial area of cardiovascular drugs, where Bristol-Myers has a strong franchise.

Novartis of Switzerland has said before that it is prepared to make a large acquisition because it wants to expand its presence in the U.S., but its first priority is to build its U.S. business internally.

French drug maker Sanofi-Synthelabo already co-markets two big-selling drugs with Bristol-Myers. It has a rich pipeline but has almost no sales force in the U.S.

Pharmacia, meanwhile, has a growing cancer franchise and may see Bristol-Myers as a means to leap into the top tier of the oncology world. Pharmacia, based in Peapack, N.J., is headed by Fred Hassan, an aggressive executive who has long expressed the desire for another merger.

Any huge drug firm formed by such a takeover might improve earnings by significantly reducing costs. But such a behemoth would require even greater productivity from the research labs to fuel growth. Several recent mergers, such as the one that formed GlaxoSmithKline, have failed to solve the problem of poor production from the drug company labs.

-- Gautam Naik in London, Vanessa Fuhrmans in Frankfurt and Scott Hensley in New York contributed to this article.

Write to Geeta Anand at geeta.anand@wsj.com9 and Michael Waldholz at michael.waldholz@wsj.com10

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Updated April 5, 2002 8:15 a.m. EST


 

Copyright 2002 Dow Jones & Company, Inc. All Rights Reserved

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Questran
 
cholestyramine resin
 
When used in addition to diet and exercise, this medication helps to reduce cholesterol levels in the blood. It works by binding to cholesterol-like substances, called bile acids, in the intestines and preventing them from being absorbed into the body. It can also be used to treat bile obstruction and diarrhea caused by short bowel syndrome. Cholestyramine may be used to relieve itchiness associated with partial blockage of bile ducts.

Your doctor may choose to use this medication for other conditions not listed here. If you're unsure why you are taking this medication, contact your doctor.

 
Cholestyramine resin is taken in a dose of 4 g (1 packet) one to six times daily depending on circumstances. The powder must be mixed with water (60 mL to 90 mL, or 2 to 3 ounces) or other fluids (milk, fruit juice, or other non-carbonated beverage) prior to taking. The powder may also be mixed with highly fluid soups or pulpy fruits with high moisture such as applesauce or crushed pineapple. Other medicines should be taken at least one hour before or four to six hours after cholestyramine resin.
 
Powder
 
People who have bile ducts that are blocked completely and those who are allergic to cholestyramine powder or any of its ingredients should not take this drug.
 
The most common adverse reaction is constipation, especially when taking a high dose and in people over 60 years of age. Most instances of constipation are mild and go away with time. Some people may need to reduce their dose or stop this treatment. Fecal impaction and aggravation of hemorrhoids may occur.

Less frequent side effects:

  • abdominal discomfort
  • gas
  • nausea
  • vomiting
  • diarrhea
  • heartburn
  • loss of appetite
  • fatty stools
  • easy bruising or bleeding
 
Cholestyramine resin should not be taken in its dry form. Always mix the drug with water or other fluids before taking it.

Pregnancy: Since cholestyramine resin is not absorbed, it is not expected to cause harm to the unborn baby when taken during pregnancy in recommended doses. The drug may reduce the absorption of fat-soluble vitamins (vitamins A and D). This should be taken into account when planning for vitamin intake when pregnant.

Breast-feeding: Nursing mothers should exercise caution when taking cholestyramine resin. The possible lack of proper vitamin absorption may have an effect on nursing infants.

Children: The effects of this drug on children are not known. Experts recommend, however, that drug therapy be considered in children 10 years or older who have tried diet therapy but still have unacceptable high serum cholesterol levels. In certain situations where a young child has extremely high serum cholesterol levels, drug treatment may even be started before 10 years of age. If the child is started on drug therapy, a carefully planned diet therapy should also be continued in order to obtain best results


Cholestyramine can bind many different drugs before they get absorbed into the body. People taking this medication should take other drugs at least one hour before or four to six hours after cholestyramine resin (or at as great an interval as possible) to avoid reducing their absorption.

Tell your doctor or prescriber about all prescription, over-the-counter (non-prescription), and herbal medications that you are taking. Also tell them about any supplements you take. Since caffeine, decongestants, alcohol, the nicotine from cigarettes, or street drugs can affect the action of many medications, you should let your prescriber know if you use them. Depending on your specific circumstances, your doctor may want you to:

  • stop taking one of the medications,
  • change one of the medications to another,
  • change how you are taking one or both of the medications, or
  • leave everything as is.

An interaction between two medications does not always mean that you must stop taking one of them. In many cases, interactions are intended or are managed by close monitoring. Speak to your doctor about how any drug interactions are being managed or should be managed.


 

The contents of the MediResource Site are for informational purposes only. Always seek the advice of your physician or other qualified health provider with any questions you may have regarding a medical condition.

disclaimer

© Virtual Learning Inc. 2000


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