EDTA BY RECTAL SUPPOSITORY IS POORLY ABSORBED AND POTENTIALLY DANGEROUS
|
EDTA BY RECTAL SUPPOSITORY IS POORLY ABSORBED AND POTENTIALLY DANGEROUS Elmer M. Cranton, M.D. EDTA rectal suppositories are being promoted as a substitute for intravenous chelation, despite research showing that EDTA is very poorly absorbed by rectum and also damages to the mucosal lining. Published data show that the colon and rectum absorb very little EDTA.(1) 51Cr-labeled EDTA is used as a radioactive tracer to study abnormal intestinal permeability precisely because it is not well absorbed. When EDTA enters the circulation it is rapidly excreted in the urine. In one study the authors determined that 85% of an intravenous dose of EDTA was recovered in the urine after 6 hours.(1) They also reported that when a saline solution of EDTA was administered by enema, only “. . . 7% of the 51Cr-EDTA instilled into the colon can be recovered in urine over the next 6 hours.”(1) These data show that very little EDTA is absorbed, even when distributed throughout the colon by enema. Even less would be absorbed if administered by suppository and limited to the rectum. Another study has been deceptively cited by proponents of EDTA suppositories, who erroneously state that it provides evidence for safety.(2) The opposite is true. That study showed a high incidence of damage to the lining of the colon and rectum from EDTA. A 250-ml enema of a 0.5% solution of EDTA was administered to a group of dogs. Half of those dogs suffered with fresh mucosal hemorrhages of the colon and rectum two hours after instillation of EDTA. Rectal suppositories will release all of their EDTA in a small area, producing a higher local concentration for a prolonged period of time, while an enema dilutes the EDTA throughout the entire colon. Even with a lower concentration, half the dogs suffered mucosal hemorrhages.(1) Rectal cancer is common. An important defense against cancer is superoxide dismutase (SOD). SOD is a metallo-enzyme that absolutely requires zinc and copper, or manganese to function. EDTA has a very high affinity for all three of those metals. If EDTA is sustained at high concentrations from suppositories, it would bind those essential metals and remove them from mucosal cells lining the rectum, inactivating intracellular SOD and other vital metalloenzymes. Latency for rectal cancer can take years for transformation from benign to malignant cells. It would require quite a long study to prove that repeated use of rectal EDTA is safe. REFERENCES
1.
Elia M, Behens C, Northrop C, Wraight P, Neale G:
Evaluation of mannitol, lactulose and 51Cr-labeled
ethylenediaminetetra-acetate as markers of intestinal
permeability in man. Clinical Science 1987;Aug
73(2):197-204. 2. Rabau MY, Baratz M, Rozen P: Na2 ethylenediaminetetraacetic acid retention enema in dogs: Biochemical and histological response. Gen Pharmacol 1991;22(2):329-30.
|
|
I promise to answer your message -- click here to send me a personal message
|
SUBSCRIBE: The Wednesday Letter is a free electronic monthly newsletter written and published by Karl Loren. You can view more than 50 back issues of this publication by clicking here. The Wednesday Letter subscription list is maintained on a secure server, no name is ever given or sold to anyone, and it is never used except for this Newsletter. It is automatically published on the Tuesday night just before the first Wednesday of every month. You can subscribe to this free monthly electronic letter by entering your eMail address and name below. You will then automatically receive a request for confirmation, sent to whatever address you have entered. If you do NOT receive this confirmation request, then you will not be subscribed. There may have been an error with your address and you should resubmit. The letter is never sent twice to the same address -- so you do not have to worry about a duplicate subscription. When you receive this confirmation request you must reply to it, or your subscription will not become active. No one can subscribe your name, and address, without you being notified, and if you get an unwanted notice of subscription you only need to DO NOTHING and the subscription will NOT be active.
REMOVAL: You can remove yourself from the subscription list in several different ways. Click here to read about this entire newsletter system. Every edition of The Wednesday Letter is delivered to your address with YOUR name and address in view on the letter, with a link that allows you to remove THAT name from the subscription list. If you try to send this removal message from an address different from the one you used to send in your original confirmation, then you will get a warning notice first, sent to the subscription address, asking you to confirm that you want to be removed from the list -- by replying to THAT request for confirmation, you will then be automatically removed. Thus, no one else can unsubscribe you, from some other computer, without your knowledge. But, if you send in the unsubscribe notice from the same machine used to receive the Letter, then the removal from the subscription list is automatic.
Personal Message: When you send a personal message to Karl Loren, you will receive a personal reply as per his instructions. Karl pledges that every personal message will get a personal answer. When you provide your mail address, we will send you free information including our free catalog and a cassette tape lecture by Karl Loren about heart disease, no charge, by mail, even if outside the US. You can select particular information you would like to receive, along with the free cassette tape and catalog.
You can reach Vibrant Life in many ways, including by mail to Vibrant Life, 2808 N. Naomi St., Burbank, CA 91504. Within the US and Canada, use the toll free number: (800) 523-4521, the local number: (818) 558-1799, the FAX: (818) 558-7299, eMail to kimberly@oralchelation.com or any one of the hundreds of message forms throughout the 50 web sites. Vibrant Life normally ships the same day we get an order. There are message forms on each of the 100,000+ pages on this and other sites where you can communicate with Vibrant Life. Check out our companion site, at: http://www.oralchelation.net where Karl's 2000 page book is published. Karl Loren is the author and webmaster for this BOOK, as well as for another web site about ORAL CHELATION. His personal philosophical articles are at PHILOSOPHY.
Copyright © May 20, 2008 6:24 AM by Karl Loren on behalf of Vibrant Life, ALL RIGHTS RESERVED. Permission is granted for non-commercial downloading, copying, distribution or redistribution on two conditions: One, that some form of copyright notice is included in every copy distributed or copied, showing the copyright belonging to Vibrant Life, Burbank, CA, at www.oralchelation.com . The second condition is that the material is not to be used for any purpose contrary to the purposes and objectives of this site. This permission does not extend to materials on this site which are copyrighted by others.